October 5

Click HERE to download the full program

Please note change of venue!

The ISN Forefronts Symposium will take place at the new auditorium of the  “AMREP Education Centre” located in the Alfred Hospital, Melbourne, Victoria and which is located next to the Baker IDI Heart and Diabetes Institute, Melbourne

08.00 – 18.00  
Registration Desk open

9.00 – 10.30
Session I: Micro RNA and Extracellular Matrix Accumulation
Chairs: Prof. Hui Lan and Dr. Phillip Kantharidis

The Epigenetic Control of Human Development and Disease: Characterization of Long Noncoding Rnas in a Mouse Model of Diabetic Nephropathy
John Mattick, IMB, University of Queensland, Queensland, Australia

Novel Mediators of Regression and Progression in Diabetic Nephropathy
Catherine Godson, University College Dublin, Ireland

MicroRNA in Renal Fibrosis
Phillip Kantharidis, Baker IDI Heart and Diabetes Institute, Melbourne, Australia

Oral Presentation chosen from abstract:

• Lan Hui, The Chinese University of Hong Kong, China – “MicroRNA-29 Inhibits Diabetic Nephropathy by Targeting TGF-b/Smad3-NF-κB-Th1 Pathways”
  

• Aaron McClelland, Baker IDI Heart & Diabetes Institute, Melbourne, Australia – “miR-21 Regulates Renal Fibrogenesis via a Mechanism that involves SMAD7 in a Model of Diabetic Nephropathy”

10:30 - 11:00
Coffee Break

11:00 - 12:30
Session II: ATP Production and Bioenergetics
Chairs:  A/Prof. Josephine Forbes and Prof. Dale Abel

Biochemistry & Genetics of Energy Production
David Thorburn, Murdoch Children’s Research Institute, Melbourne, Australia

Mitochondrial Mutations and Renal Disease
Melinda Coughlan, Baker IDI Heart and Diabetes Institute, Melbourne, Australia

Tubular Renin, Succinate and Diabetes
Janos Peti-Peterdi, University of Southern California, Los Angeles CA, USA

12:30 - 14:00
Lunch Break/Poster viewing I

14.00 – 15.30
Session III: T regulatory Cells in the Tubulointerstitial Compartment
Chairs:  Prof David Harris

The Transcription Factors Blimp-1 and IRF4 Control the Differentiation and Function of Effector Regulatory T Cells
Erika Cretney, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

Regulatory T Cells: Their Potential Roles in Renal Disease
Richard Kitching, Monash Medical Centre, Australia

Therapeutic and Atypical Tregs in Renal Disease
Stephen Alexander, Centre for Kidney Research, Children’s Hospital Westmead, Sydney, Australia –

Oral Presentations chosen from abstract:

• Harshini Mudaliar, University of Sydney, Australia – “The Role of Toll-Like Receptor Proteins (TLR) 2 And 4 in Mediating Inflammation in Human Proximal Tubular Cells (PTCs)”
  

• Sungjin Chung, The Catholic University of Korea Seoul, Korea – “Haploinsufficiency of the bis Gene Aggravates Diabetic Nephropathy by Increasing Oxidative Stress”

15:30 - 16:00
Afternoon Coffee Break

16.00 – 17.30
Session IV:  Renal Glucose Uptake and Gluconeogenesis
Chairs:  Prof. Dick deZeeuw and Prof. Catherine Godson

Role of SGLTs in glucose homeostasis and kidney function in diabetes
Volker Vallon, University of California, San Diego, USA

SGLT2 transporters
Carol Pollock, University of Sydney, New South Wales, Australia

Oral Presentationschosen from abstract:

• Berthold Hocher, University of Potsdam, Germany – “DPP-4 Inhibition with Linagliptin Delays the Progression of Diabetic Nephropathy in db/db mice”

20:00
Official Dinner